作者单位:Univ Hosp Leuven, Dept Gastroenterol, Leuven, Belgium[1]Genentech Res & Early Dev, San Francisco, CA USA[2]Hosp Clin Barcelona, Inst Invest Biomed August Pi i Sunyer, Ctr Invest Biomed Red Enfermedades[3]Icahn Sch Med Mt Sinai, Div Gastroenterol, 1 Gustave L Levy Pl, New York, NY 10029 USA[4]