The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding

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作者： Madigan, James P. ^[1] ; Hou, Feng ^[2] ; Ye, Linlei ^[3] ; Hu, Jicheng ^[4] ; Dong, Aiping ^[5] ; Tempel, Wolfram ; Yohe, Marielle E. ; Randazzo, Paul A. ; Jenkins, Lisa M. Miller ; Gottesman, Michael M. ; Tong, Yufeng

作者单位： NCI, Lab Cell & Mol Biol, Ctr Canc Res, NIH, Bethesda, MD 20892 USA ^[1] NCI, Pediat Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA ^[2] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON M5G 1L7, Canada ^[3] Univ Toronto, Struct Genom Consortium, Toronto, ON M5G 1L7, Canada ^[4] NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA ^[5]

关键词 phosphorylation Akt PKB 14-3-3 protein E3 ubiquitin ligase protein stability ubiquitylation (ubiquitination)tuberous sclerosis complex (TSC)mTORC1 phospho-switch

发布时间 2019-04-18

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