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Transporter biology in drug approval: Regulatory aspects

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作者： Maeda,K. ^[1] ; Sugiyama,Y. ^[2]

作者单位： Department of Sugiyama Laboratory, RIKEN Innovation Center, RIKEN Research Cluster for Innovation ^[1] Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, University of ^[2]

关键词 (SLC22A6)Drug interaction number (DIN)Dynamic model False-negative predictions MATE2-K (SLC47A2)Multidrug and toxin extrusion (MATE)1 (SLC47A1)Multidrug resistance 1 (MDR1 P-glycoprotein (P-gp))OAT3 (SLC22A8)OATP1B3 (SLCO1B3)Organic anion transporter (OAT)1 Organic anion transporting polypeptide (OATP)1B1 (SLCO1B1)Organic cation transporter (OCT)2 (SLC22A2)Static model Transporter-mediated drug-drug interaction

发布时间 2013-11-20

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Molecular Aspects of Medicine

2013年34卷2/3期

711-718页

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Molecular Aspects of Medicine

2013年34卷2/3期

711-718页

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Transporter biology in drug approval: Regulatory aspects

Molecular Aspects of Medicine

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Molecular Aspects of Medicine

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Transporter biology in drug approval: Regulatory aspects

Molecular Aspects of Medicine

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Molecular Aspects of Medicine

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