The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides

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作者： Braendli-Baiocco, Annamaria ^[1] ; Festag, Matthias ^[2] ; Erichsen, Kamille Dumong ^[3] ; Persson, Robert ^[4] ; Mihatsch, Michael J. ^[5] ; Fisker, Niels ; Funk, Juergen ; Mohr, Susanne ; Constien, Rainer ; Ploix, Corinne ; Brady, Kevin ; Berrera, Marco ; Altmann, Bernd ; Lenz, Barbara ; Albassam, Mudher ; Schmitt, Georg ; Weiser, Thomas ; Schuler, Franz ; Singer, Thomas ; Tessier, Yann

作者单位： F Hoffmann La Roche Ltd, Roche Innovat Ctr New York, Pharmaceut Sci, Roche Pharmaceut Res & Early ^[1] Roche Diagnost GmbH, Roche Pharmaceut Res & Early Dev Bioanalyt Res &, Roche Innovat Ctr Munich, D ^[2] F Hoffmann La Roche Ltd, Roche Innovat Ctr Basel, Pharmaceut Sci, Roche Pharmaceut Res & Early Dev ^[3] Roche Innovat Ctr Copenhagen, Pharmaceut Sci, Roche Pharmaceut Res & Early Dev, DK-2970 Horsholm ^[4] Univ Hosp Basel, Inst Pathol, CH-4031 Basel, Switzerland ^[5]

关键词 locked nucleic acid minipig non-human primate single-stranded oligonucleotide safety assessment

发布时间 2018-03-07

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