换一批Substrate selectivity of human cytochrome P4502C9: importance of residues 476, 365, and 114 in recognition of diclofenac and sulfaphenazole and in mechanism-based inactivation by tienilic acid
第一作者：
Melet A.
作者：
关键词
Yeast-expressed cyp2csSite-directed mutagenesisDrug metabolismHydroxylationDifference visible spectroscopyActive-site topologyIi-ii interactionsAmino-acidYeast-cellsActive-sitesBinding site(s)-mephenytoin 4'-hydroxylaseMonooxygenase activitiesStructural determinantsLiver microsomesHuman cyp2c19Derivatives
发布时间
2013-11-20
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