Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression

导出原文传递

翻译打印收藏纠错

作者： Gillman,K.W. ^[1] ; Parker,M.F. ^[2] ; Silva,M. ^[3] ; Degnan,A.P. ^[4] ; Tora,G.O. ; Lodge,N.J. ; Li,Y.-W. ; Lelas,S. ; Taber,M. ; Krause,R.G. ; Bertekap,R.L. ; Newton,A.E. ; Pieschl,R.L. ; Lengyel,K.D. ; Johnson,K.A. ; Taylor,S.J. ; Bronson,J.J. ; MacOr,J.E.

作者单位： Lead Evaluation and Mechanistic Biochemistry, Bristol-Myers Squibb Research and Development, 5 ^[1] Neuroscience Discovery Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway ^[2] Neuroscience Discovery Biology, Bristol-Myers Squibb Research and Development, 5 Research Parkway ^[3] Pharmaceutical Candidate Optimization-Metabolism and Pharmacokinetics, Bristol-Myers Squibb ^[4]

关键词 Depression Neurokinin 1 antagonists Receptor occupancy Serotonin transporter inhibitors

发布时间 2013-11-20

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交