Design, Synthesis, and Evaluation of 2-Methyl- and 2-Amino-N-aryl-4,5-dihydrothiazolo[4,5-h]quinazolin-8-amines as Ring-Constrained 2-Anilino-4-(thiazol-5-yl)pyrimidine Cyclin-Dependent Kinase Inhibitors

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作者： McIntyre, NA ^[1] ; McInnes, C ^[2] ; Griffiths, G ; Barnett, AL ; Kontopidis, G ; Slawin, AMZ ; Jackson, W ; Thomas, M ; Zheleva, DI ; Wang, SD ; Blake, DG ; Westwood, NJ ; Fischer, PM

作者单位： Cyclacel Ltd, Dundee DD1 5JJ, Scotland. ^[1] Univ St Andrews, Sch Chem & Biomed Sci Res Complex, St Andrews KY16 9ST, Fife, Scotland. ^[2]

关键词 RNA-POLYMERASE-II ALPHA-HYDROXYMETHYLENE-KETONES CDK INHIBITORS BIOLOGICAL-ACTIVITY TERMINAL DOMAIN CELL-CYCLE SYSTEMS CANCER 2-METHYL-6-HYDROXYMETHYLENE-4 5 6 7-TETRAHYDROBENZOTHIAZOL-7-ONE CRYSTALLOGRAPHY

发布时间 2013-11-20

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Journal of Medicinal Chemistry

2010年53卷5期

2136-2145页

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Design, Synthesis, and Evaluation of 2-Methyl- and 2-Amino-N-aryl-4,5-dihydrothiazolo[4,5-h]quinazolin-8-amines as Ring-Constrained 2-Anilino-4-(thiazol-5-yl)pyrimidine Cyclin-Dependent Kinase Inhibitors

Journal of Medicinal Chemistry

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Design, Synthesis, and Evaluation of 2-Methyl- and 2-Amino-N-aryl-4,5-dihydrothiazolo[4,5-h]quinazolin-8-amines as Ring-Constrained 2-Anilino-4-(thiazol-5-yl)pyrimidine Cyclin-Dependent Kinase Inhibitors

Journal of Medicinal Chemistry

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Journal of Medicinal Chemistry

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