Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+ depletion and the unfolded protein response

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作者： Sehgal, Pankaj ^[1] ; Szalai, Paula ^[2] ; Olesen, Claus ^[3] ; Praetorius, Helle A. ^[4] ; Nissen, Poul ; Christensen, Soren Brogger ; Engedal, Nikolai ; Moller, Jesper V.

作者单位： Univ Oslo, Ctr Mol Med Norway NCMM, Nord European Mol Biol Lab EMBL Partnership Mol M, POB 1137 ^[1] Danish Res Fdn, Ctr Membrane Pumps Cells & Dis Pumpkin, DK-8000 Aarhus, Denmark ^[2] Aarhus Univ, Dept Biomed, DK-8000 Aarhus, Denmark ^[3] Univ Copenhagen, Dept Drug Design & Pharmacol, DK-2100 Copenhagen, Denmark ^[4]

关键词 apoptosis calcium endoplasmic reticulum (ER)stromal interaction molecule 1 (STIM1)unfolded protein response (UPR)

发布时间 2018-03-28

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