Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms

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作者： Wan, Honghe ^[1] ; Schroeder, Gretchen M. ^[1] ; Hart, Amy C. ^[1] ; Inghrim, Jennifer ^[1] ; Grebinski, James ^[1] ; Tokarski, John S. ^[1] ; Lorenz, Matthew V. ^[1] ; You, Dan ^[1] ; Mcdevie, Theresa ^[1] ; Penhallow, Becky ^[1] ; Vuppugalla, Ragini ^[1] ; Zhang, Yueping ^[1] ; Gu, Xiaomei ^[1] ; Iyer, Ramaswamy ^[1] ; Lombardo, Louis J. ^[1] ; Trainor, George L. ^[1] ; Ruepp, Stefan ^[1] ; Lippy, Jonathan ^[1] ; Blat, Yuval ^[1] ; Sack, John S. ^[1] ; Khan, Javed A. ^[1] ; Stefanski, Kevin ^[1] ; Sleczka, Bogdan ^[1] ; Mathur, Arvind ^[1] ; Sun, Jung-Hui ^[1] ; Wong, Michael K. ^[1] ; Wu, Dauh-Rurng ^[1] ; Li, Peng ^[1] ; Gupta, Anuradha ^[1] ; Arunachalam, P. N. ^[1] ; Pragalathan, Bala ^[1] ; Narayanan, Sankara ^[1] ; Nanjundaswamy, K. C. ^[1] ; Kuppusamy, Prakasam ^[1] ; Purandare, Ashok V. ^[1]

作者单位： Bristol Myers Squibb R&D, Princeton, NJ 08543 USA ^[1]

关键词 JAK2 selective inhibitor myeloproliferative neoplasm structure-guided design BMS-911543

发布时间 2016-02-29

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