Proteasome-based mechanisms of intrinsic and acquired bortezomib resistance in non-small cell lung cancer

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作者： DeWilt,L.H.A.M. ^[1] ; Jansen,G. ^[2] ; Assaraf,Y.G. ^[3] ; VanMeerloo,J. ^[4] ; Cloos,J. ^[5] ; Schimmer,A.D. ^[6] ; Chan,E.T. ^[7] ; Kirk,C.J. ; Peters,G.J. ; Kruyt,F.A.E.

作者单位： Fred Wyszkowski Cancer Research Lab, Department of Biology, Technion-Israel Institute of Technology ^[1] Department of Medical Oncology, VU University Medical Center, Amsterdam, Netherlands ^[2] Onyx Pharmaceuticals, South San Francisco, United States ^[3] Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands ^[4] Department of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, Netherlands ^[5] Princess Margeret Hospital, Ontario Cancer Institute, Toronto, Canada ^[6] Department of Medical Oncology, University of Groningen, University Medical Center Groningen ^[7]

关键词 β5 proteasome subunit Bortezomib Lung cancer Mutation Proteasome inhibitors Resistance

发布时间 2013-11-20

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