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Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2

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第一作者: Huang,J.
作者: Huang,J. [1] ; Huffman,J.E. [2] ; Yamkauchi,M. [3] ; Trompet,S. [4] ; Asselbergs,F.W. [5] ; Sabater-Lleal,M. [6] ; Trégou?t,D.-A. [7] ; Chen,W.-M. [8] ; Smith,N.L. [9] ; Kleber,M.E. [10] ; Shin,S.-Y. [11] ; Becker,D.M. [12] ; Tang,W. [13] ; Dehghan,A. [14] ; Johnson,A.D. [15] ; Truong,V. [16] ; Folkersen,L. [17] ; Yang,Q. [18] ; Oudot-Mellkah,T. [19] ; Buckley,B.M. [20] ; Moore,J.H. [21] ; Williams,F.M.K. [22] ; Campbell,H. [23] ; Silbernagel,G. [24] ; Vitart,V. [25] ; Rudan,I. [26] ; Tofler,G.H. [27] ; Navis,G.J. [28] ; Destefano,A. [29] ; Wright,A.F. [30] ; Chen,M.-H. [31] ; DeCraen,A.J.M. [32] ; Worrall,B.B. [33] ; Rudnicka,A.R. [34] ; Rumley,A. [35] ; Bookman,E.B. [36] ; Psaty,B.M. [37] ; Chen,F. [38] ; Keene,K.L. [39] ; Franco,O.H. [40] ; B?hm,B.O. [41] ; Uitterlinden,A.G. [42] ; Carter,A.M. [43] ; Jukema,J.W. [44] ; Sattar,N. [45] ; Bis,J.C. [46] ; Ikram,M.A. [47] ; Sale,M.M. [48] ; McKnight,B. [49] ; Fornage,M. [50] ; Ford,I. [51] ; Taylor,K. [52] ; Slagboom,P.E. [53] ; McArdle,W.L. [54] ; Hsu,F.-C. [55] ; Franco-Cereceda,A. [56] ; Goodall,A.H. [57] ; Yanek,L.R. [58] ; Furie,K.L. [59] ; Cushman,M. [60] ; Hofman,A. [61] ; Witteman,J.C.M. [62] ; Folsom,A.R. ; Basu,S. ; Matijevic,N. ; VanGilst,W.H. ; Wilson,J.F. ; Westendorp,R.G.J. ; Kathiresan,S. ; Reilly,M.P. ; Tracy,R.P. ; Polasek,O. ; Winkelmann,B.R. ; Grant,P.J. ; Hillege,H.L. ; Cambien,F. ; Stott,D.J. ; Lowe,G.D. ; Spector,T.D. ; Meigs,J.B. ; Marz,W. ; Eriksson,P. ; Becker,L.C. ; Morange,P.-E. ; Soranzo,N. ; Williams,S.M. ; Hayward,C. ; VanDerHarst,P. ; Hamsten,A. ; Lowenstein,C.J. ; Strachan,D.P. ; O'Donnell,C.J.
作者单位: Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, United [1] Division of Biostatistics, University of Minnesota, Minneapolis, MN, United States [2] Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States [3] ALSPAC Laboratory, Department of Social Medicine, University of Bristol, Bristol, United Kingdom [4] INSERM UMRS 937, Pierre et Marie Curie University, Paris, France, ICAN Institute for [5] Division of Epidemiology, School of Public Health, University of Texas Health Science Center at [6] National Heart, Lung, and Blood Institute, Framingham Heart Study, 73 Mt Wayte St, Framingham, MA [7] Robertson Center for Biostatistics, University of Glasgow, Glasgow, United Kingdom [8] Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia [9] Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, United [10] Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen [11] Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands, Netherlands Consortium [12] Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet [13] Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom [14] Department of Epidemiology, University of Washington, Seattle, WA, United States, Group Health [15] Department of Gerontology and Geriatrics, Leiden University Medical Center, Netherlands [16] Department of Biostatistics, Boston University, Boston, MA, United States [17] INSERM UMRS 937, Pierre et Marie Curie University, Paris, France [18] Department of Genetics, Gesiel School of Medicine at Dartmouth, Lebanon, NH, United States [19] General Medicine Division, Massachusetts General Hospital, Boston, MA, United States, Department of [20] Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom [21] Centre for Population Health Sciences, University of Edinburgh, United Kingdom [22] Division of Genomic Medicine, National Human Genome Research Institute, Bethesda, MD, United States [23] Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA [24] Department of Medicine, University of Washington, Seattle, WA, United States [25] Department of Angiology, Swiss Cardiovascular Center, Bern, Switzerland [26] Division of Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, United States [27] Department of Biology and Center for Health Disparities Research, East Carolina University [28] Department of Internal Medicine I, University of Ulm Medical Centre, Ulm, Germany, LKC School of [29] Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm [30] Department of Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY [31] Department of Epidemiology, University of Washington, Seattle, WA, United States [32] Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht [33] Warren Alpert Medical School, Brown University, Providence, RI, United States [34] Cardiology Team Sachsenhausen, Frankfurt am Main, Germany [35] Royal North Shore Hospital, University of Sydney, Australia [36] Department of Cardiology, Leiden University Medical Center, Netherlands, Department of Gerontology [37] Department of Twin Research and Genetic Epidemiology, King's College London, United Kingdom [38] Department of Internal Medicine, University of Groningen, Groningen, Netherlands [39] Department of Pathology, University of Vermont, Burlington, VT, United States [40] INSERM UMRS 1062, Aix-Marseille Université, Marseille, France [41] Department of Epidemiology, University of Washington, Seattle, WA, United States, Department of [42] Department of Molecular Epidemiology, Leiden University Medical Center, Netherlands, Netherlands [43] MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital [44] Department of Cardiology, Leiden University Medical Center, Netherlands, Durrer Center for [45] Department of Medicine, University of Vermont, Burlington, VT, United States, Department of [46] Department of Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands, Netherlands [47] Cardiology Division, Massachusetts General Hospital, Boston, MA, United States, Cardiovascular [48] Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden [49] Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands, Department of Radiology [50] Department of Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands [51] Department of Biochemistry and Molecular Genetics, Center for Public Health Genomics, University of [52] Division of Population Health Sciences and Education, St George's University of London, London [53] Department of Internal Medicine II-Cardiology, University of Ulm Medical Centre, Ulm, Germany [54] Division of Cardiovascular and Diabetes Research, Leeds University, Leeds, United Kingdom [55] Department of Public Health Sciences, University of Virginia, Charlottesville, VA, United States [56] Wellcome Trust Sanger Institute, Hinxton, United Kingdom, MRC Centre for CAiTE, School of Social [57] Department of Pharmacology and Therapeutics, University College Cork, Ireland [58] Mannheim Institute of Public Health, Medical Faculty of Mannheim, University of Heidelberg [59] Hemostasis Laboratory, University of Texas Health Science Center at Houston, Houston, TX, United [60] Wellcome Trust Sanger Institute, Hinxton, United Kingdom, Department of Twin Research and Genetic [61] Department of Twin Research and Genetic Epidemiology, King's College London, United Kingdom, BHF [62]
发布时间 2014-06-29
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