作者单位:Cardiff Univ, Inst Mol & Expt Med, Cardiff CF14 4YS, S Glam, Wales[1]Cardiff Univ, Cochrane Inst Primary Care & Publ Hlth, Cardiff CF14 4YS, S Glam, Wales[2]Cardiff Univ, South East Wales Trials Unit, Cardiff CF14 4YS, S Glam, Wales[3]Cardiff Univ, Inst Med Educ, Cardiff CF14 4YS, S Glam, Wales[4]