Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3- methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl] thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

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作者： Yoshida,T. ^[1] ; Akahoshi,F. ^[2] ; Sakashita,H. ; Kitajima,H. ; Nakamura,M. ; Sonda,S. ; Takeuchi,M. ; Tanaka,Y. ; Ueda,N. ; Sekiguchi,S. ; Ishige,T. ; Shima,K. ; Nabeno,M. ; Abe,Y. ; Anabuki,J. ; Soejima,A. ; Yoshida,K. ; Takashina,Y. ; Ishii,S. ; Kiuchi,S. ; Fukuda,S. ; Tsutsumiuchi,R. ; Kosaka,K. ; Murozono,T. ; Nakamaru,Y. ; Utsumi,H. ; Masutomi,N. ; Kishida,H. ; Miyaguchi,I. ; Hayashi,Y.

作者单位： R and D Strategy Dept., Corporate Strategy Division, Mitsubishi Chemical Corporation, 1000 ^[1] Research Division, Mitsubishi Tanabe Pharma Corporation, 2-2-50, Kawagishi, Toda-shi, Saitama 335 ^[2]

关键词 Bicyclic heteroarylpiperazine DPP-4 inhibitor Thiazolidine

发布时间 2013-11-20

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