换一批Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
第一作者：
Malik, Rainer
作者：
Malik, Rainer [1]
;
Chauhan, Ganesh [2]
;
Traylor, Matthew [3]
;
Sargurupremraj, Muralidharan [4]
;
Okada, Yukinori [5]
;
Mishra, Aniket [6]
;
Rutten-Jacobs, Loes [7]
;
Giese, Anne-Katrin [8]
;
van der Laan, Sander W. [9]
;
Gretarsdottir, Solveig [10]
;
Anderson, Christopher D. [11]
;
Chong, Michael [12]
;
Adams, Hieab H. H. [13]
;
Ago, Tetsuro [14]
;
Almgren, Peter [15]
;
Amouyel, Philippe [16]
;
Ay, Hakan [17]
;
Bartz, Traci M. [18]
;
Benavente, Oscar R. [19]
;
Bevan, Steve [20]
;
Boncoraglio, Giorgio B. [21]
;
Brown, Robert D., Jr. [22]
;
Butterworth, Adam S. [23]
;
Carrera, Caty [24]
;
Carty, Cara L. [25]
;
Chasman, Daniel I. [26]
;
Chen, Wei-Min [27]
;
Cole, John W. [28]
;
Correa, Adolfo [29]
;
Cotlarciuc, Ioana [30]
;
Cruchaga, Carlos [31]
;
Danesh, John [32]
;
de Bakker, Paul I. W. [33]
;
DeStefano, Anita L. [34]
;
den Hoed, Marcel [35]
;
Duan, Qing [36]
;
Engelter, Stefan T. [37]
;
Falcone, Guido J. [38]
;
Gottesman, Rebecca F. [39]
;
Grewal, Raji P. [40]
;
Gudnason, Vilmundur [41]
;
Gustafsson, Stefan [42]
;
Haessler, Jeffrey [43]
;
Harris, Tamara B. [44]
;
Hassan, Ahamad [45]
;
Havulinna, Aki S. [46]
;
Heckbert, Susan R. [47]
;
Holliday, Elizabeth G. [48]
;
Howard, George [49]
;
Hsu, Fang-Chi [50]
;
Hyacinth, Hyacinth I. [51]
;
Ikram, M. Arfan [52]
;
Ingelsson, Erik [53]
;
Irvin, Marguerite R. [54]
;
Jian, Xueqiu [55]
;
Jimenez-Conde, Jordi [56]
;
Johnson, Julie A. [57]
;
Jukema, J. Wouter [58]
;
Kanai, Masahiro [59]
;
Keene, Keith L. [60]
;
Kissela, Brett M. [61]
;
Kleindorfer, Dawn O. [62]
;
Kooperberg, Charles [63]
;
Kubo, Michiaki [64]
;
Lange, Leslie A. [65]
;
Langefeld, Carl D. [66]
;
Langenberg, Claudia [67]
;
Launer, Lenore J. [68]
;
Lee, Jin-Moo [69]
;
Lemmens, Robin [70]
;
Leys, Didier [71]
;
Lewis, Cathryn M. [72]
;
Lin, Wei-Yu [73]
;
Lindgren, Arne G. [74]
;
Lorentzen, Erik [75]
;
Magnusson, Patrik K. [76]
;
Maguire, Jane [77]
;
Manichaikul, Ani [78]
;
McArdle, Patrick F. [79]
;
Meschia, James F. [80]
;
Mitchell, Braxton D. [81]
;
Mosley, Thomas H. [82]
;
Nalls, Michael A. [83]
;
Ninomiya, Toshiharu [84]
;
O'Donnell, Martin J. [85]
;
Psaty, Bruce M. [86]
;
Pulit, Sara L. [87]
;
Rannikmae, Kristiina [88]
;
Reiner, Alexander P. [89]
;
Rexrode, Kathryn M. [90]
;
Rice, Kenneth [91]
;
Rich, Stephen S. [92]
;
Ridker, Paul M. [93]
;
Rost, Natalia S. [94]
;
Rothwell, Peter M. [95]
;
Rotter, Jerome I. [96]
;
Rundek, Tatjana [97]
;
Sacco, Ralph L. [98]
;
Sakaue, Saori [99]
;
Sale, Michele M. [100]
;
Salomaa, Veikko [101]
;
Sapkota, Bishwa R. [102]
;
Schmidt, Reinhold [103]
;
Schmidt, Carsten O. [104]
;
Schminke, Ulf [105]
;
Sharma, Pankaj [106]
;
Slowik, Agnieszka [107]
;
Sudlow, Cathie L. M. [108]
;
Tanislav, Christian [109]
;
Tatlisumak, Turgut [110]
;
Taylor, Kent D. [111]
;
Thijs, Vincent N. S. [112]
;
Thorleifsson, Gudmar [113]
;
Thorsteinsdottir, Unnur [114]
;
Tiedt, Steffen ;
Trompet, Stella ;
Tzourio, Christophe ;
van Duijn, Cornelia M. ;
Walters, Matthew ;
Wareham, Nicholas J. ;
Wassertheil-Smoller, Sylvia ;
Wilson, James G. ;
Wiggins, Kerri L. ;
Yang, Qiong ;
Yusuf, Salim ;
Bis, Joshua C. ;
Pastinen, Tomi ;
Ruusalepp, Arno ;
Schadt, Eric E. ;
Koplev, Simon ;
Bjorkegren, Johan L. M. ;
Codoni, Veronica ;
Civelek, Mete ;
Smith, Nicholas L. ;
Tregouet, David A. ;
Christophersen, Ingrid E. ;
Roselli, Carolina ;
Lubitz, Steven A. ;
Ellinor, Patrick T. ;
Tai, E. Shyong ;
Kooner, Jaspal S. ;
Kato, Norihiro ;
He, Jiang ;
van der Harst, Pim ;
Elliott, Paul ;
Chambers, John C. ;
Takeuchi, Fumihiko ;
Johnson, Andrew D. ;
Sanghera, Dharambir K. ;
Melander, Olle ;
Jern, Christina ;
Strbian, Daniel ;
Fernandez-Cadenas, Israel ;
Longstreth, W. T., Jr. ;
Rolfs, Arndt ;
Hata, Jun ;
Woo, Daniel ;
Rosand, Jonathan ;
Pare, Guillaume ;
Hopewell, Jemma C. ;
Saleheen, Danish ;
Stefansson, Kari ;
Worrall, Bradford B. ;
Kittner, Steven J. ;
Seshadri, Sudha ;
Fornage, Myriam ;
Markus, Hugh S. ;
Howson, Joanna M. M. ;
Kamatani, Yoichiro ;
Debette, Stephanie ;
Dichgans, Martin
作者单位：
Univ Clin Rostock, Albrecht Kossel Inst, Rostock, Germany
[1]
Univ Med Greifswald, SHIP KEF, Inst Community Med, Greifswald, Germany
[2]
Univ Technol Sydney, Fac Hlth, Ultimo, NSW, Australia
[3]
Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA
[4]
Washington Univ, Sch Med, Dept Neurol Radiol & Biomed Engn, St Louis, MO USA
[5]
Boston Univ, Sch Publ Hlth, Boston, MA USA
[6]
Jagiellonian Univ, Dept Neurol, Krakow, Poland
[7]
Natl Inst Hlth & Welf, Helsinki, Finland
[8]
NIH, Natl Inst Aging, Lab Neurogenet, Bldg 10, Bethesda, MD 20892 USA
[9]
Med Univ Graz, Dept Neurol, Graz, Austria
[10]
Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland
[11]
Univ Autonoma Barcelona, Inst Hosp Mar Invest Med, Neurol Dept, Neurovasc Res Grp NEUVAS, Barcelona
[12]
IRCCS, Ist Neurol Carlo Besta, Dept Cerebrovasc Dis, Milan, Italy
[13]
Wake Forest Sch Med, Ctr Publ Hlth Genom, Winston Salem, NC USA
[14]
Univ Virginia, Sch Med, Dept Neurol, Charlottesville, VA 22908 USA
[15]
Univ Washington, Dept Biostat, Seattle, WA 98195 USA
[16]
RIKEN Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan
[17]
Univ Calif Los Angeles, Med Ctr, Los Angeles Biomed Res Inst Harbor, Inst Translat Genom & Populat
[18]
Lund Univ, Dept Clin Sci Lund, Neurol, Lund, Sweden
[19]
Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, New York, NY USA
[20]
Univ Alabama Birmingham, Sch Publ Hlth, Birmingham, AL 35294 USA
[21]
Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA
[22]
Kyushu Univ, Grad Sch Med Sci, Dept Epidemiol & Publ Hlth, Fukuoka, Japan
[23]
Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA
[24]
Emory Univ, Sch Med, Dept Pediat, Aflac Canc & Blood Disorder Ctr, Atlanta, GA USA
[25]
Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
[26]
Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, U1219, Bordeaux, France
[27]
Framingham Heart Dis Epidemiol Study, Framingham, MA USA
[28]
Sorbonne Univ, UPMC Univ Paris 06, Team Genom & Pathophysiol Cardiovasc Dis, INSERM,UMR S 1166
[29]
Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA
[30]
Univ Lille, CHU Lille, INSERM, U 1171, Lille, France
[31]
Mayo Clin, Dept Neurol, Rochester, MN USA
[32]
Childrens Natl Med Ctr, Childrens Res Inst, Washington, DC 20010 USA
[33]
Univ Penn, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA
[34]
Iceland Heart Assoc Res Inst, Kopavogur, Iceland
[35]
Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Stroke Div, Heidelberg, Vic, Australia
[36]
Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, London
[37]
Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA
[38]
Mayo Clin, Dept Neurol, Jacksonville, FL USA
[39]
Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39216 USA
[40]
Natl Ctr Global Hlth & Med, Res Inst, Dept Gene Diagnost & Therapeut, Tokyo, Japan
[41]
Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands
[42]
Leiden Univ, Med Ctr, Sect Gerontol & Geriatr, Dept Internal Med, Leiden, Netherlands
[43]
Univ Alabama Birmingham, Sch Publ Hlth, Epidemiol, Birmingham, AL 35294 USA
[44]
Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA
[45]
Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka, Japan
[46]
Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
[47]
Univ Hosp, LMU Munich, Inst Stroke & Dementia Res ISD, Munich, Germany
[48]
Univ Cambridge, Div Clin Neurosci, Stroke Res Grp, Cambridge, England
[49]
Washington Univ, Sch Med, Dept Psychiat, Hope Ctr Program Prot Aggregat & Neurodegenerat H, St
[50]
Univ Gothenburg, Sahlgrenska Acad, Inst Neuroscience & Physiol, Dept Clin Neurosci Neurol
[51]
Erasmus Univ, Med Ctr, Dept Epidemiol, Genet Epidemiol Unit, Rotterdam, Netherlands
[52]
Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
[53]
Univ Gothenburg, Bioinformat Core Facil, Gothenburg, Sweden
[54]
Imperial Coll London, Dept Epidemiol & Biostat, London, England
[55]
Basel Univ Hosp, Dept Neurol, Basel, Switzerland
[56]
Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands
[57]
Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, England
[58]
Stanford Univ, Sch Med, Div Cardiovasc Med, Dept Med, Stanford, CA USA
[59]
Kings Coll London, Dept Med & Mol Genet, London, England
[60]
Osaka Univ, Grad Sch Med, Dept Stat Genet, Osaka, Japan
[61]
Uppsala Univ, Genet & Pathol & Sci Life Lab, Dept Immunol, Uppsala, Sweden
[62]
NIH, Natl Inst Aging, Lab Epidemiol & Populat Sci, Bldg 10, Bethesda, MD 20892 USA
[63]
Indian Inst Sci, Ctr Brain Res, Bangalore, Karnataka, India
[64]
Hunter Med Res Inst, Publ Hlth Stream, New Lambton, NSW, Australia
[65]
Univ N Carolina, Dept Genet, Chapel Hill, NC USA
[66]
Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA
[67]
Univ Tartu, Inst Biomed & Translat Med, Dept Pathophysiol, Tartu, Estonia
[68]
Univ Texas Hlth Sci Ctr Houston, Brown Fdn Inst Mol Med, Houston, TX 77030 USA
[69]
Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Jackson, MS 39216 USA
[70]
Univ Virginia, Dept Publ Hlth Sci, Ctr Publ Hlth Genom, Charlottesville, VA USA
[71]
Wake Forest Sch Med, Dept Biostat, Winston Salem, NC USA
[72]
Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands
[73]
Harvard Med Sch, MGH, Dept Neurol, Boston, MA USA
[74]
Univ Oklahoma, Hlth Sci Ctr, Coll Med, Dept Pediat, Oklahoma City, OK 73190 USA
[75]
Univ Cambridge, Dept Publ Hlth & Primary Care, MRC BHF Cardiovasc Epidemiol Unit, Cambridge, England
[76]
Univ Lincoln, Sch Life Sci, Lincoln, England
[77]
Univ Cincinnati, Coll Med, Cincinnati, OH USA
[78]
Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Pathol & Genet, Gothenburg, Sweden
[79]
Lund Univ, Dept Clin Sci, Malmo, Sweden
[80]
Imperial Coll London, Natl Heart & Lung Inst, London, England
[81]
Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England
[82]
Helsinki Univ Hosp, Dept Neurol, Helsinki, Finland
[83]
MGH, Ctr Genom Med, Boston, MA USA
[84]
Univ Colorado Denver, Dept Med, Anschutz Med Campus, Aurora, CO USA
[85]
Univ Med Greifswald, Dept Neurol, Greifswald, Germany
[86]
Leeds Teaching Hosp NHS Trust, Leeds Gen Infirm, Dept Neurol, Leeds, W Yorkshire, England
[87]
NIH, Natl Inst Aging, Intramural Res Program, Bldg 10, Bethesda, MD 20892 USA
[88]
Leiden Univ, Dept Cardiol, Med Ctr, Leiden, Netherlands
[89]
East Carolina Univ, Dept Biol, Greenville, NC USA
[90]
Univ Autonoma Barcelona, Vall Hebron Hosp, Vall Hebron Inst Res, Neurovasc Res Lab,Neurol Dept
[91]
Univ Glasgow, Sch Med Dent & Nursing, Glasgow, Lanark, Scotland
[92]
Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore
[93]
Univ Utrecht, Univ Med Ctr Utrecht, Div Heart & Lungs, Lab Expt Cardiol,Dept Cardiol, Utrecht
[94]
Univ Washington, Cardiovasc Hlth Res Unit, Dept Biostat, Seattle, WA 98195 USA
[95]
Univ Mississippi, Med Ctr, Sch Med, Div Geriatr, Jackson, MS 39216 USA
[96]
DeCODE Genet AMGEN Inc, Reykjavik, Iceland
[97]
Univ Virginia, Ctr Publ Hlth Gen, Charlottesville, VA USA
[98]
Univ Lille, Risk Factors & Mol Determinants Aging Related Dis, Inst Pasteur Lille, INSERM,LabEx
[99]
Univ Cambridge, Sch Clin Med, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England
[100]
Univ Leuven, KU Leuven, Dept Neurosci Expt Neurol, Leuven, Belgium
[101]
MGH, J Philip Kistler Stroke Res Ctr, Dept Neurol, Boston, MA USA
[102]
Royal Holloway Univ London, Inst Cardiovasc Res, London, England
[103]
Univ British Columbia, Brain Res Ctr, Div Neurol, Fac Med, Vancouver, BC, Canada
[104]
RIKEN Ctr Integrat Med Sci, Lab Stat Anal, Yokohama, Kanagawa, Japan
[105]
McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada
[106]
Univ Florida, Coll Pharm, Dept Pharmacotherapy & Translat Res, Gainesville, FL USA
[107]
Justus Liebig Univ, Dept Neurol, Giessen, Germany
[108]
McGill Univ, Dept Human Genet, Montreal, PQ, Canada
[109]
Broad Inst Harvard, Program Med & Populat Genet, Cambridge, MA USA
[110]
Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA
[111]
Icahn Sch Med Mt Sinai, Icahn Inst Genom & Multiscale Biol, Dept Genet & Genom Sci, New York, NY
[112]
SF Med Ctr, Neurosci Inst, Trenton, NJ USA
[113]
Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA
[114]
发布时间
2019-01-12
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Nature Genetics
Nature Genetics
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