作者单位:Childrens Mercy Kansas City, Ward Family Heart Ctr, Kansas City, MO USA[1]Univ Manchester, Ctr Appl Pharmacokinet Res, Div Pharm & Optometry, Sch Hlth Sci,Fac Biol Med &[2]Childrens Mercy Kansas City, Div Clin Pharmacol Toxicol & Therapeut Innovat, Kansas City, MO USA[3]