Comparative Study between the 3D‐Liver Spheroid Models Developed from HepG2 and Immortalized Hepatocyte‐Like Cells with Primary Hepatic Stellate Coculture for Drug Metabolism Analysis and Anticancer Drug Screening-论文-万方医学网

Comparative Study between the 3D‐Liver Spheroid Models Developed from HepG2 and Immortalized Hepatocyte‐Like Cells with Primary Hepatic Stellate Coculture for Drug Metabolism Analysis and Anticancer Drug Screening

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作者： Arunsajee Sae‐be ^[1] ; Teerawat Wiwatpanit ^[2] ; Thaveechai Varatthan ^[3] ; Thanaphon Namporn ^[4] ; Sasiwat Laungkulldej ^[5] ; Ratthiya Thiabma ^[6] ; Atchara Jaiboonma ; Khanit Sa‐ngiamsuntorn ; Daniel Elson ; Alexandra E. Porter ; Korbtham Sathirakul ; Suradej Hongeng ; Pakatip Ruenraroengsak

作者单位： Department of Pharmacy,Mahidol University ^[1] National Center for Genetic Engineering and Biotechnology (BIOTEC),National Science and Technology ^[2] Department of Biochemistry,Mahidol University ^[3] Department of Surgery and Cancer,South Kensington Campus ^[4] Department of Materials and London Centre for Nanotechnology,Imperial College London ^[5] Department of Pediatrics,Mahidol University ^[6]

关键词 3D cocultures CYP450 enzymes doxorubicin hepatocellular carcinoma immortalized human hepatocyte‐like cells Liver spheroids midazolam metabolism

发布时间 2024-04-24

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