Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers

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作者： Watterson, Scott H. ^[1] ; De Lucca, George V. ^[1] ; Shi, Qing ^[1] ; Langevine, Charles M. ^[1] ; Liu, Qingjie ^[1] ; Batt, Douglas G. ^[1] ; Bertrand, Myra Beaudoin ^[1] ; Gong, Hua ^[1] ; Dai, Jun ^[1] ; Yip, Shiuhang ^[1] ; Li, Peng ^[1] ; Sun, Dawn ^[1] ; Wu, Dauh-Rurng ^[1] ; Wang, Chunlei ^[1] ; Zhang, Yingru ^[1] ; Traeger, Sarah C. ^[1] ; Pattoli, Mark A. ^[1] ; Skala, Stacey ^[1] ; Cheng, Lihong ^[1] ; Obermeier, Mary T. ^[1] ; Vickery, Rodney ^[1] ; Discenza, Lorell N. ^[1] ; D'Arienzo, Celia J. ^[1] ; Zhang, Yifan ^[1] ; Heimrich, Elizabeth ^[1] ; Gillooly, Kathleen M. ^[1] ; Taylor, Tracy L. ^[1] ; Pulicicchio, Claudine ^[1] ; McIntyre, Kim W. ^[1] ; Galena, Michael A. ^[1] ; Tebben, Andy J. ^[1] ; Muckelbauer, Jodi K. ^[1] ; Chang, ChiehYing ^[1] ; Rampulla, Richard ^[1] ; Mathur, Arvind ^[1] ; Salter-Cid, Luisa ^[1] ; Barrish, Joel C. ^[1] ; Carter, Percy H. ^[1] ; Fura, Aberra ^[1] ; Burke, James R. ^[1] ; Tino, Joseph A. ^[1]

作者单位： Bristol Myers Squibb Res & Dev, POB 4000, Princeton, NJ 08543 USA ^[1]

发布时间 2017-04-06

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