Synthesis, cannabinoid receptor affinity, and molecular modeling studies of substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides

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作者： Silvestri R ^[1] ; Cascio MG ^[2] ; La Regina G ^[3] ; Piscitelli F ^[4] ; Lavecchia A ^[5] ; Brizzi A ; Pasquini S ; Botta M ; Novellino E ; Di Marzo V

作者单位： Sapienza Univ Roma, Dipartimento Studi Farmaceut, Fdn Cenci Bolognetti, Ist Pasteur, I-00185 Rome, Italy ^[1] Univ Siena, Dipartimento Farmaco Chim Tecnol, Polo Sci Univ San Miniato, I-53100 Siena, Italy ^[2] Univ Naples Federico 2, Dipartimento Chim Farmaceut & Tossicol, I-80131 Naples, Italy ^[3] CNR, Ist Chim Biolmol, I-80078 Naples, Italy ^[4] syk.uit.no ^[5]

关键词 PROTEIN-COUPLED RECEPTORS SEROTONIN 5-HT2A RECEPTOR CB1 RECEPTOR INVERSE AGONISTS ENDOCANNABINOID SYSTEM ENDOGENOUS CANNABINOIDS ENDOVANILLOID SYSTEMS BIOLOGICAL-PROPERTIES SELECTIVE ANTAGONIST THERAPEUTIC TARGETS

发布时间 2013-11-20

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