High-dose linaclotide is effective and safe in patients with chronic constipation: A phase III randomized, double-blind, placebo-controlled study with a long-term open-label extension study in Japan

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作者： Fukudo, Shin ^[1] ; Miwa, Hiroto ^[2] ; Nakajima, Atsushi ^[3] ; Kinoshita, Yoshikazu ^[4] ; Kosako, Masanori ^[5] ; Hayashi, Kenta ^[6] ; Akiho, Hiraku ^[7] ; Kuroishi, Kentaro ^[8] ; Johnston, Jeffrey M. ^[9] ; Currie, Mark ^[10] ; Ohkusa, Toshifumi

作者单位： Yokohama City Univ, Dept Gastroenterol & Hepatol, Yokohama, Kanagawa, Japan ^[1] Astellas Pharma Inc, Japan Asia Clin Dev 1, Dev, Tokyo, Japan ^[2] Hyogo Coll Med, Dept Internal Med, Div Gastroenterol, Nishinomiya, Hyogo, Japan ^[3] Jikei Univ, Kashiwa Hosp, Sch Med, Dept Internal Med, Kashiwa, Chiba, Japan ^[4] Astellas Pharma Inc, Japan Asia Data Sci, Dev, Tokyo, Japan ^[5] Shimane Univ, Dept Gastroenterol, Fac Med, Izumo, Shimane, Japan ^[6] Astellas Pharma Inc, Tokyo, Japan ^[7] Astellas Pharma Inc, Regulatory Affairs Japan, Tokyo, Japan ^[8] Tohoku Univ, Grad Sch Med, Dept Behav Med, Sendai, Miyagi, Japan ^[9] Ironwood Pharmaceut Inc, Cambridge, MA USA ^[10]

关键词 chronic constipation diarrhea guanylate cyclase C activator linaclotide stool consistency

发布时间 2019-09-20

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