首页> Journal of Medicinal Chemistry> Synthesis, SAR, and Series Evolution of Novel Oxadiazole-Containing 5-Lipoxygenase Activating Protein Inhibitors: Discovery of 2-[4-(3-{(R)-1-[4-(2-Amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915)

Synthesis, SAR, and Series Evolution of Novel Oxadiazole-Containing 5-Lipoxygenase Activating Protein Inhibitors: Discovery of 2-[4-(3-{(R)-1-[4-(2-Amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915)

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第一作者： Takahashi, Hidenori

作者： Takahashi, Hidenori ^[1] ; Riether, Doris ^[2] ; Bartolozzi, Alessandra ^[1] ; Bosanac, Todd ^[2] ; Berger, Valentina ^[2] ; Binetti, Ralph ^[2] ; Broadwater, John ^[2] ; Chen, Zhidong ^[1] ; Crux, Rebecca ^[1] ; De Lombaert, Stephane ^[2] ; Dave, Rajvee ^[1] ; Dines, Jonathon A. ^[2] ; Fadra-Khan, Tazmeen ^[2] ; Flegg, Adam ^[2] ; Garrigou, Michael ^[2] ; Hao, Ming-Hong ^[1] ; Huber, John ^[2] ; Hutzler, J. Matthew ^[2] ; Kerr, Steven ^[1] ; Kotey, Adrian ^[2] ; Liu, Weimin ^[2] ; Lo, Ho Yin ^[1] ; Loke, Pui Leng ^[2] ; Mahaney, Paige E. ^[2] ; Morwickt, Tina M. ^[2] ; Napier, Spencer ^[2] ; Olague, Alan ^[2] ; Pack, Edward ^[2] ; Padyana, Anil K. ^[2] ; Thomson, David S. ^[3] ; Tye, Heather ^[2] ; Wu, Lifen ^[3] ; Zindell, Renee M. ^[3] ; Abeywardane, Asitha ^[3] ; Simpson, Thomas ^[2]

作者单位： Evotec, Abingdon OX14 4RZ, Oxon, England ^[1] Boehringer Ingelheim Pharmaceut Inc, Dept Med Chem, Ridgefield, CT 06877 USA ^[2] Boehringer Ingelheim Pharmaceut Inc, Dept Cardiometabol Dis, Ridgefield, CT 06877 USA ^[3]

发布时间 2015-04-26

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