Synthetic peptides coupled to the surface of liposomes effectively induce SARS coronavirus-specific cytotoxic T lymphocytes and viral clearance in HLA-A*0201 transgenic mice.

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作者： Ohno, S. ^[1] ; Kohyama, S. ^[2] ; Taneichi, M. ^[3] ; Moriya, O. ^[4] ; Hayashi, H. ^[5] ; Oda, H. ; Mori, M. ; Kobayashi, A. ; Akatsuka, T. ; Uchida, T. ; Matsui, M.

作者单位： Department of Microbiology, Faculty of Medicine, Saitama Medical University, Moroyama-cho, Iruma-gun, Saitama 350-0495, Japan ^[1] Drug Delivery System Development Division, Nippon Oil and Fat Corporation, Tokyo 150-6019, Japan ^[2] Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Musashimurayama-city, Tokyo 208-0011, Japan ^[3] Department of Pathological Biochemistry, Faculty of Pharmaceutical Sciences, Josai University, Sakado-city, Saitama 350-0295, Japan ^[4] bDepartment of Pathological Biochemistry, Faculty of Pharmaceutical Sciences, Josai University, Sakado-city, Saitama 350-0295, Japan ^[5]

关键词 cytotoxic T lymphocytes disease models epitopes histocompatibility antigens immunization laboratory animals liposomes severe acute respiratory syndrome synthetic peptides vaccination vaccines mice Severe acute respiratory syndrome coronavirus

发布时间 2013-11-20

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