The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumourgrowth

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作者： Bago, Ruzica ^[1] ; Sommer, Eeva ^[2] ; Castel, Pau ^[3] ; Crafter, Claire ^[4] ; Bailey, Fiona P. ; Shpiro, Natalia ; Baselga, Jose ; Cross, Darren ; Eyers, Patrick A. ; Alessi, Dario R.

作者单位： AstraZeneca, CRUK Cambridge Inst, Oncol iMED, Cambridge, England ^[1] Univ Dundee, Coll Life Sci, MRC Prot Phosphorylat & Ubiquitylat Unit, Dundee, Scotland ^[2] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, 1275 York Ave, New York, NY 10021 ^[3] Univ Liverpool, Inst Integrat Biol, Dept Biochem, Liverpool, Merseyside, England ^[4]

关键词 mTORC1 mTORC2 NanoString PI3K and NDRG1 protein kinase inhibitors SGK3 signal transduction inhibitors

发布时间 2018-08-24

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