Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus

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作者： Wang, Alan Xiangdong ^[1] ; Chen, Jie ^[2] ; Zhao, Qian ^[3] ; Sun, Li-Qiang ^[4] ; Friborg, Jacques ; Yu, Fei ; Hernandez, Dennis ; Good, Andrew C. ; Klei, Herbert E. ; Rajamani, Ramkumar ; Mosure, Kathy ; Knipe, Jay O. ; Li, Danshi ; Zhu, Jialong ; Levesque, Paul C. ; McPhee, Fiona ; Meanwell, Nicholas A. ; Scola, Paul M.

作者单位： Bristol Myers Squibb Res & Dev, Global Clin Res, 5,Res Pkwy, Wallingford, CT 06492 USA ^[1] Bristol Myers Squibb Res & Dev, Dept Discovery Chem, 5 Res Pkwy, Wallingford, CT 06492 USA ^[2] Bristol Myers Squibb Res & Dev, Dept Computat Aided Drug Design, Res Pkwy, Wallingford, CT 06492 USA ^[3] Bristol Myers Squibb Res & Dev, Dept Virol, 5 Res Pkwy, Wallingford, CT 06492 USA ^[4]

关键词 HCV NS3/4A serine protease inhibitors Tripeptide acylsulfonamides C4 aryl C4 hydroxy-proline Potent and orally bioavailable Cardiovascular profiles

发布时间 2018-01-30

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