Combined lysis of thrombus with ultrasound and systemic tissue plasminogen activator for emergent revascularization in acute ischemic stroke (CLOTBUST-ER): design and methodology of a multinational phase 3 trial

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作者： Schellinger, Peter D. ^[1] ; Alexandrov, Andrei V. ^[2] ; Barreto, Andrew D. ^[3] ; Demchuk, Andrew M. ^[4] ; Tsivgoulis, Georgios ^[5] ; Kohrmann, Martin ^[6] ; Alleman, John ^[7] ; Howard, Virginia ^[8] ; Howard, George ; Alexandrov, Anne W. ; Brandt, Gordon ; Molina, Carlos A.

作者单位： Univ Tennessee, Hlth Sci Ctr, Dept Neurol, Memphis, TN 38163 USA ^[1] Univ Texas Hlth Sci Ctr Houston, Dept Neurol, Houston, TX 77030 USA ^[2] Univ Calgary, Hotchkiss Brain Inst, Dept Clin Neurosci & Radiol, Calgary, AB, Canada ^[3] Univ Hosp Erlangen, Dept Neurol, Erlangen, Germany ^[4] Univ Alabama Birmingham, Birmingham, AL USA ^[5] Johannes Wesling Med Ctr, Dept Neurol, Minden, Germany ^[6] Vall dHebron Hosp, Barcelona, Spain ^[7] Cerevast Therapeut Inc, Redmond, WA USA ^[8]

关键词 acute stroke therapy clinical trial fibrinolysis rt-PA sonolysis thrombolysis ultrasound

发布时间 2016-01-29

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