换一批Impact of immunosenescence and inflammaging on the effects of immune checkpoint inhibitors
Impact of immunosenescence and inflammaging on the effects of immune checkpoint inhibitors
摘要Immune checkpoint inhibitors (ICIs) are employed in immunotherapeutic applications for patients with weakened immune systems and can improve the ability of T cells to kill cancer cells. Although ICIs can potentially treat different types of cancers in various groups of patients, their effectiveness may differ among older individuals. The reason ICIs are less effective in older adults is not yet clearly understood, but age-related changes in the immune system, such as immunosenescence and inflammation, may play a role. Therefore, this review focuses on recent advances in understanding the effects of immunosenescence and inflammation on the efficacy of ICIs.
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关键词
ImmunosenescenceInflammagingImmune checkpoint inhibitorImmunosenescenceInflammagingImmune checkpoint inhibitor
栏目名称
DOI
10.1016/j.cpt.2023.08.001
发布时间
2026-03-31（万方平台首次上网日期，不代表论文的发表时间）
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