摘要Ulcerative colitis (UC) is a chronic inflammatory disease affecting the colon, with an increasing incidence worldwide. Disease pathogenesis is multifactorial and involves genetic predisposition, epithelial barrier defects, dysregulated immune responses, and environmental factors[1,2]. Long-standing UC leads to several complications such as megacolon, inflammation of the eye and joints, and/or colon cancer[3]. Eaden et al. revealed that 25-year chronic UC increases colorectal cancer risk by as much as 34％[4]. Their study further indicated that UC etiology is related to the environment, gene variation, intestinal microflora, and altered immune response, but precise mechanisms and pathogenesis remain unclear. Several drugs and surgical approaches are used to treat UC, but may present drug resistance issues or severe side effects[5]. Therefore, novel UC treatments are demanded.