摘要Objective This study aimed to investigate the association between fruit and vegetable intake and arterial stiffness.Methods We conducted a cohort-based study comprising 6,628 participants with arterial stiffness information in the Prediction for Atherosclerotic Cardiovascular Disease Risk in China(China-PAR)project.A semi-quantitative food-frequency questionnaire was used to assess baseline(2007-2008)and recent(2018-2021)fruit and vegetable intake.We assessed changes in fruit and vegetable intake from 2007-2008 to 2018-2021 in 6,481 participants.Arterial stiffness was measured using the arterial velocity-pulse index(AVI)and arterial pressure-volume index(API).Elevated AVI and API values were defined according to diverse age reference ranges.Results Multivariable-adjusted linear regression models revealed that every 100 g/d increment in fruit and vegetable intake was associated with a 0.11 decrease in AVI(B =-0.11;95%confidence interval[CI]:-0.20,-0.02)on average,rather than API(B = 0.02;95%CI:-0.09,0.13).The risk of elevated AVI(odds ratio[OR]= 0.82;95%CI:0.70,0.97)is 18%lower in individuals with high intake(≥500 g/d)than in those with low intake(<500 g/d).Furthermore,maintaining a high intake in the past median of 11.5 years of follow-up was associated with an even lower risk of elevated AVI compared with a low intake at both baseline and follow-up(OR = 0.64;95%CI:0.49,0.83).Conclusion Fruit and vegetable intake was negatively associated with arterial stiffness,emphasizing recommendations for adherence to fruit and vegetable intake for the prevention of arterial stiffness.