摘要The pervasive utilization of industrial substances has escalated human exposure to cadmium (Cd), a metal associated with long-term negative health outcomes such as renal dysfunction, neurological disorders, and various cancers[1]. Once ingested by humans, Cd interacts with cysteine-rich metallothioneins (MTs) which have metal-binding and antioxidant properties and is subsequently transported to the kidney[2]. Several isoforms of MTs exist, including MT1 (encompassing MT1A, MT1B, MT1E, MT1F, MT1G, MT1H, MT1M, and MT1X), MT2 (specifically MT2A), MT3, and MT4, all of which are located on chromosome 16q13. Actually, these isoforms exhibit tissue-specific and cell-specific alternative splicing, leading to differences in expression efficiency[3].