换一批WNT5A Regulated by miR154-5p is Associated with Angiopoiesis and Invasion of Placental Site Trophoblastic Tumor(PSTT)
摘要Placental site trophoblastic tumor (PSTT), a rare gestational trophoblastic neoplasm (GTN), exhibits slow growth, late-onset metastasis, and chemotherapy insensitivity[1,2]. The invasive capacity of trophoblasts induces angiogenesis in PSTT, yet the specific mechanism remains unclear[3]. PSTT is typically resistant to chemotherapy and hysterectomy stands as the primary therapeutic choice for patients with an overall cure rate of approximately 75％-80％[4,5]. Therefore, investigating the precise emergence and progression of PSTT is crucial, aiming to identify novel targets for diagnosis and therapy.
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