摘要Objective To assess the independent and combined effects of air pollutants,meteorological factors,and greenspace exposure on new tuberculosis(TB)cases.Methods TB case data from Shanghai(2013-2018)were obtained from the Shanghai Center for Disease Control and Prevention.Environmental data on air pollutants,meteorological variables,and greenspace exposure were obtained from the National Tibetan Plateau Data Center.We employed a distributed-lag nonlinear model to assess the effects of these environmental factors on TB cases.Results Increased TB risk was linked to PM2.5,PM10,and rainfall,whereas NO2,SO2,and air pressure were associated with a reduced risk.Specifically,the strongest cumulative effects occurred at various lags:PM2.5(RR=1.166,95%CI:1.026-1.325)at 0-19 weeks;PM10(RR=1.167,95%CI:1.028-1.324)at 0-18 weeks;NO2(RR=0.968,95%CI:0.938-0.999)at 0-1 weeks;SO2(RR=0.945,95%CI:0.894-0.999)at 0-2 weeks;air pressure(RR=0.604,95%CI:0.447-0.816)at 0-8 weeks;and rainfall(RR=1.404,95%CI:1.076-1.833)at 0-22 weeks.Green space exposure did not significantly impact TB cases.Additionally,low temperatures amplified the effect of PM2.5 on TB.Conclusion Exposure to PM2.5,PM10,and rainfall increased the risk of TB,highlighting the need to address air pollutants for the prevention of TB in Shanghai.