摘要Objective To investigate chronic hepatitis C virus(HCV)infection's effect on gestational liver function,pregnancy and delivery complications,and neonatal development.Methods A total of 157 HCV antibody-positive(anti-HCV[+])and HCV RNA(+)patients(Group C)and 121 anti-HCV(+)and HCV RNA(-)patients(Group B)were included as study participants,while 142 anti-HCV(-)and HCV RNA(-)patients(Group A)were the control group.Data on biochemical indices during pregnancy,pregnancy complications,delivery-related information,and neonatal complications were also collected.Results Elevated alanine aminotransferase(ALT)rates in Group C during early,middle,and late pregnancy were 59.87%,43.95%,and 42.04%,respectively—significantly higher than Groups B(26.45%,15.70%,10.74%)and A(23.94%,19.01%,6.34%)(P<0.05).Median ALT levels in Group C were significantly higher than in Groups A and B at all pregnancy stages(P<0.05).No significant differences were found in neonatal malformation rates across groups(P>0.05).However,neonatal jaundice incidence was significantly greater in Group C(75.16%)compared to Groups A(42.25%)and B(57.02%)(χ2=33.552,P<0.001).HCV RNA positivity during pregnancy was an independent risk factor for neonatal jaundice(OR=2.111,95%CI 1.242-3.588,P=0.006).Conclusions Chronic HCV infection can affect the liver function of pregnant women,but does not increase the pregnancy or delivery complication risks.HCV RNA(+)is an independent risk factor for neonatal jaundice.