摘要Silicosis,a major persistent occupational disease in China,is a progressive and irreversible pulmonary fibrosis disease with unclear pathogenesis.Cellular senescence,a state of stable cell cycle arrest that is recognized as a key underlying factor in age-related fibroproliferative disorders,plays an important role in chronic lung diseases,particularly pulmonary fibrosis.We previously reported that SiO2-stimulated mice and alveolar type II epithelial cells develop cellular senescence,which is involved in silicosis formation in alveolar type II epithelial cells[1].Cellular senescence may play an important role in silicosis development;however,the exact underlying mechanisms are not fully understood.
作者单位School of public health,Hebei Key Laboratory for Organ Fibrosis Research,North China University of Science and Technology,Tangshan 063210,Hebei China[1]NHC Key Laboratory of Pneumoconiosis Department of Pulmonary and Critical Care Medicine,The First Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi,China[2]School of public health,Hebei Key Laboratory for Organ Fibrosis Research,North China University of Science and Technology,Tangshan 063210,Hebei China;Health Science Center,North China University of Science and Technology,Tangshan 063210,Hebei,China[3]School of Basic Medicine,Hebei Key Laboratory for Chronic Diseases,North China University of Science and Technology,Tangshan 063210,Hebei,China[4]
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