摘要Skin cutaneous melanoma (SKCM),a highly invasive malignant tumor originating from skin melanocytes,poses a significant threat to public health[1,2]. Its development is closely associated with multiple factors,such as ultraviolet radiation,gene mutations,and immune escape. Among these,imbalance in the immune surveillance and clearance of tumor cells is a crucial link to disease progression[3,4]. Tripartite motif-containing 27,which belongs to the TRIM protein family and is encoded by the TRIM27 gene,contains the RING,B-box,and coiled-coil domains. It participates in biological processes such as cell-cycle regulation,signal transduction,and immune response mainly by modifying target proteins through ubiquitination.Notably,increasing evidence indicates that TRIM27 is closely associated with the tumor immune microenvironment and contributes to cancer immune escape via multiple mechanisms,thereby promoting tumor development[5]. However,the role of TRIM27 in SKCM remains unclear,thus prompting our investigation to elucidate this.