换一批摘要In recent years,Wnt/β-catenin signaling has been identified as a key player in embryogene-sis and human diseases.Canonical Wnt signaling pathway is controlled by a variety of classic molecules like Wnt,β-catenin,Axin,APC,GSK-3β and CKl,which interact and coordinate to regulate the ex-pressions of cell signaling molecules.The latest evidences suggest that some components of the Wnt/β-catenin signaling,like APC,GSK-3β,CKl,Dkk2 and WISE,play dual roles different from what they have been thought previously.Here we reviewed some recent discoveries on the canonical Wnt/β-catenin signaling pathway to provide some new ideas and principles for signaling transduction studies.
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关键词
Wnt蛋白质类信号传导胞间信号肽类和蛋白质类Wnt proteinsSignal transductionIntercellular signaling peptides and proteins
医学主题词
蛋白质类(Proteins)信号传导(Signal Transduction)胞间信号肽类和蛋白质类(Intercellular Signaling Peptides and Proteins)
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DOI
10.3969/j.issn.1671-167X.2010.02.028
发布时间
2010-06-02（万方平台首次上网日期，不代表论文的发表时间）
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