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Bioprinting of skin constructs for wound healing

摘要Extensive burns and full-thickness skin wounds are difficult to repair. Autologous split-thickness skin graft (ASSG) is still used as the gold standard in the clinic. However, the shortage of donor skin tissues is a serious problem. A potential solution to this problem is to fabricate skin constructs using biomaterial scaffolds with or without cells. Bioprinting is being applied to address the need for skin tissues suitable for transplantation, and can lead to the development of skin equivalents for wound healing therapy. Here, we summarize strategies of bioprinting and review current advances of bioprinting of skin constructs. There will be challenges on the way of 3D bioprinting for skin regeneration, but we still believe bioprinting will be potential skills for wounds healing in the foreseeable future.

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作者单位 The Affiliated Hospital of Southwest Medical University, the department of Plastic & Burns Surgery, Tai Ping Street, Luzhou 646000, People's Republic of China [1] Sichuan Academy of Chinese Medical Sciences, Sichuan Translational Medicine Center of Chinese Medicine, Ren Min Nan Lu Road,Chengdu 610041, People's Republic of China [2] State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China;Collaborative Innovation Center for Biotherapy, Chengdu 610041, People's Republic of China [3] The Affiliated Hospital of Southwest Medical University, the department of Plastic & Burns Surgery, Tai Ping Street, Luzhou 646000, People's Republic of China;Sichuan Academy of Chinese Medical Sciences, Sichuan Translational Medicine Center of Chinese Medicine, Ren Min Nan Lu Road, Chengdu 610041, People's Republic of China [4]
栏目名称 Review
DOI 10.1186/s41038-017-0104-x
发布时间 2019-02-22
基金项目
This study was supported in part by grants from Administration of Traditional Chinese Medicine of Sichuan National Natural Science Foundation of China Foundation for Distinguished Young Scientists of Sichuan Province Project sub topics of the National 863 Project Scientific research fund for outstanding young scholars of Sichuan University Sichuan province science and technology support plan Science and technology support program of Sichuan Province
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