摘要目的 总结原发性皮肤间变性大细胞淋巴瘤(PC-ALCL)的病理形态学、免疫表型、临床表现等特点,提高对该病的认识.方法 回顾性分析14例PC-ALCL的形态学、免疫表型、临床表现等资料,总结它们的特点.结果 14例PC-ALCL中,随访结果提示13例生存,1例失访,生存时间2～53个月,平均生存时间19.8个月,中位生存时间18个月.形态学方面,瘤细胞以中-大细胞为主,多形性明显的经典型11例,免疫母细胞型2例,小细胞型1例.所有病例多数肿瘤细胞(>75%)表达CD30.结论 PC-ALCL是一种预后很好的少见淋巴瘤类型,皮肤结节、中大细胞浸润、CD30弥漫阳性为其主要病理学特征.

abstractsObjective To summarize the morphological and immunohistological and clinical manifestatical features of primary cutaneous anaplastic large cell lymphoma (PC-ALCL). Methods We analyzed retrospectively the morphological and immunohistological and clinical data of 14 cases with PC-ALCL and summarized their features. Results Fourteen cases of PC-ALCL were studied. Thirteen cases were followedup in which all cases were alive. There were 11 cases in common type which showed medium to large-sized cells with predominant pleomorphism, 2 cases in immunoblastic type and 1 case in small cell type. Immunohistochemical staining showed that more than 75 % tumor cells expressed CD30 in every case.Conclusion PC-ALCL is an uncommon subtype of lymphoma with an good prognosis. It is characterized by cutaneous nodules, the inflitartion of medium to large-sized cells and the diffuse expression of CD30.