摘要骨髓间充质干细胞(MSC)以其多向向中胚层起源细胞分化潜能及自我更新的干细胞特征,成为骨髓造血微环境中重要的构成组分及前体成分,参与胚胎血细胞的生成及维持造血,其本身及其衍生分化的基质细胞参与构建不同的造血龛结构,包括成骨细胞龛、基质细胞龛和脂肪细胞龛,经由细胞间多种黏附分子及相应信号通路或可溶性细胞因子直接或间接协同调控造血细胞的生成和分化,因此籍以MSC在支持造血细胞生成中发挥的作用,期待其潜在的治疗价值.

abstractsMesenchymal stem cells(MSC) have the ability to self-renew and differentiate into tissues of mesodermal origin (osteocytes, adipocytes, chondrocytes), and the cellular constituents of the microenvironment, largely derive from a common progenitor of mesenchymal origin. MSC themselves and their large numbers of progeny form three kinds of niches(osteoblastic niche, stromal niche and adipocyte niche)which have a fully competent microenvironment to provide appropriate signals via production of soluble factors and cell contact interactions of adhesion molecules, by which they play the role in supporting haemopoiesis and differentiation. Many of the discoveries described herein may contribute to future clinical treatments for hematopoietic, including cancer.