摘要光学基因组图谱（OGM）是一种新型非测序的遗传学分析技术，可高精度分析全基因组范围的结构变异，具有独特技术优势，并且技术流程相对简单，易于实施。近年来OGM在血液肿瘤基因组结构变异分析中的应用已经得到广泛验证和认可。越来越多的研究显示，OGM的应用可帮助改进血液肿瘤的遗传学诊断、预后分层和治疗指导。现结合第65届美国血液学会年会的报道对相关研究进展进行阐述。

abstractsOptical genome mapping (OGM) is a novel non-sequencing genetic analysis technology that enables high-precision analysis of structural variations across the entire genome. It possesses unique technical advantages, and its procedural simplicity makes it easy to implement. In recent years, the application efficacy of OGM technology in the analysis of genomic structural variations in hematologic malignancies has been widely validated and recognized. Increasing evidence indicates that the application of OGM technology can help improve the genetic diagnosis, prognostic stratification and treatment guidance of hematologic malignancies. This article draws upon pertinent reports from the 65th American Society of Hematology Annual Meeting to provide an overview of the progress in applying OGM technology for the precise diagnosis and treatment of hematologic malignancies.