国家重点研发计划项目国家自然科学基金面上项目2011年教育部"新世纪优秀人才支持计划"中国博士后科学基金面上项目陕西省自然科学基金青年项目西安交通大学第一附属医院临床研究课题重点项目(编号:XJTU1AF-CRF-2015-004).This work was part of National Key Research and Development Program of ChinaNational Natural Science Foundation of China2011 New Century Excellent Talent Support Plan of the Ministry of Education,ChinaChina Postdoctoral Science FoundationShaanxi Provincial Natural Science Foundation for Youths of ChinaClinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong University