首页 > 磁共振成像 > 血管周围间隙扩散张量成像指数在评估儿童良性Rolandic癫痫脑类淋巴系统功能及疾病状态的价值

血管周围间隙扩散张量成像指数在评估儿童良性Rolandic癫痫脑类淋巴系统功能及疾病状态的价值

Evaluation of glymphatic system activity and disease state by diffusion tensor image analysis along the perivascular space index in children with benign Rolandic epilepsy

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摘要目的探讨血管周围间隙扩散张量成像指数(diffusion tensor image analysis along the perivascular space index,DTI-ALPS index)在评价儿童良性Rolandic癫痫(Rolandic epilepsy,RE)患儿脑类淋巴系统(glymphatic system,GS)功能及疾病状态中的价值.材料与方法选取20例6～12岁的RE患儿(患儿组)与20例年龄、性别匹配的儿童(对照组)行常规MRI及MR扩散张量成像(diffusion tensor imaging,DTI)检查.定量分析两组的DTI-ALPS index.采用Pearson相关分析患儿组DTI-ALPS index与癫痫发作持续时间、发作频率及认知功能的相关性.结果患儿组DTI-ALPS index较对照组降低(患儿组:1.41±0.20,对照组:1.56±0.16;t=?2.620,P=0.013).两组DTI-ALPS index均与年龄呈正相关(患儿组r=0.483,P=0.002;对照组r=0.534,P<0.001).患儿组DTI-ALPS index与癫痫发作持续时间、发作频率呈负相关(发作持续时间r=?0.743,P<0.001;发作频率r=?0.460,P=0.044);与总智商(full intelligence quotient,FIQ)及言语智商(verbal intelligence quotient,VIQ)呈正相关(r_FIQ=0.523,P=0.014;r_VIQ=0.563,P=0.001),与操作智商(practical intelligence quotient,PIQ)无相关性.结论 DTI-ALPS index可用于评估RE患儿GS功能受损情况,在探究疾病状态中具有较高的价值.