摘要Objective To study the influence of hepatocyte growth factor (HGF) antibody on the lung expression level of matrix metalloproteinases-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1).Methods Thirty male Wistar rats were randomly divided into 3 groups:control group,model group,and intervention group.Endotoxin was intratracheally infused in the model and intervention groups.HGF antibody was injected in the rats of the intervention group from day 1 to day 14,while the same volume of saline was injected in the control group.The rats were sacrificed on day 28 after endotoxin treatment.The amounts of MMP-9 mRNA and TIMP-1 mRNA were measured by reverse transcription-polymerase chain reaction,and protein expression levels of MMP-9 and TIMP-1 were measured by immunohistochemistry.Results In the model group,both mRNA and protein expression levels of TIMP-1 were significantly increased,the same as MMP-9.In the intervention group,the increase of TIMP-1 was remarkably reduced compared with the model group,while the mRNA and protein expression levels of MMP-9 were still increased.Conclusion HGF activity may accelerate the repair of lung injury through contrary regulating the expression levels of TIMP- 1 and MMP-9.