胸段硬膜外镇痛对胸科手术患者凝血-纤溶动态平衡的影响

Effect of thoracic epidural analgesia on coagulation and fibrinolysis dynamic balance in patients undergoing major thoracic surgery

二维码有效期 120s

摘要目的:用凝血-纤溶动态图(Coagulation-fibrinolysis dynamic-pattern,CF)观察胸段硬膜外镇痛(Thoracic epiduralanalgesia,TEA)对胸科手术患者凝血-纤溶动态平衡的影响.方法:选择开胸手术(食管癌根治术和肺叶切除术)患者40例,随机分为全麻复合硬膜外镇痛(General-epidural anesthesia,GEA)组和全麻(General anaesthesia,GA)组(n=20).分别于麻醉诱导前(基础值)、关胸时、术后1、3 d晨空腹抽取前臂静脉血测血小板计数(Platelet,PLT)、纤维蛋白原(Fibrinogen,FIB)及凝血-纤溶动态描记图,并于术前及术后4～7d分别行下肢深静脉彩超检查.结果:两组FIB、凝固启动时间(Concretion startuptime,CST)、最大凝固程度(Maximum extent of coagulation,MCE)差异无统计学意义(P＞0.05);在关胸及术后,GEA组较GA组的凝血达峰值时间(Maximum coagulation time,MCT)明显延长(P＜0.05),PLT明显减少(P＜0.01),平衡时间(Balance time,BLT)和全反应时间(whole time of fibrinolysis reaction,WFT)明显缩短(P＜0.01);术后下肢深静脉血栓(Deep venous thrombosis,DVT)发生率明显降低(P＜0.05).结论:TEA可抑制开胸手术后应激引起的凝血功能增强,改善术后纤溶抑制,维持体内凝血-纤溶功能的动态平衡.