摘要Alzheimer's disease is a complex neurodegenerative ailment accompanied by cognitive problems and progressive memory loss. The main causes of the disease are indistinguishable even though aging is said to be the key risk factor, along with the hypotheses such as β-amyloid plaques, tau-proteins, neuroinflammation, and oxidative stress. Currently, Alzheimer's disease is not curable, and the available medicines are only used to provide symptom relief. Scientists and researchers have developed numerous models to study Alzheimer's disease, such as in silico methods, in vitro models of cultured rat cortical neurons, in vivo rodent models involving mice and rats, and non-rodent models as well. This review provides an insight into the modality of Alzheimer's disease treatment using medicinal plants that are natural sources with abundant bioactive substances, and traditional formulations (such as an extract from Notoginseng Radix et Rhizoma, Chinese herbal formulations (i.e., traditional Chinese medicine kidney-nourishing formula, supplements such as coenzyme Q10, alpha-lipoic acid, Ginkgo Biloba, omega-3's, and acetyl-L-carnitine). In addition, we have discussed the evaluation parameters for experimental Alzheimer's disease, which are used to assess the mechanism of memory and pharmacological effects of molecules for drug discovery and development. The common experimental analysis methods for Alzheimer's disease include behavioral, biochemical, and histological studies. This work will allow researchers to access an informative reference of traditional medicines along with experimental analysis methods in one place for Alzheimer's disease research.