摘要Doxorubicin(DOX),also known as adriamycin,is an anthracycline chemotherapy drug that exerts anticancer effects.However,the clinical application of DOX is severely limited by its cardiotoxicity.Recent researches show that the mechanism of DOX-induced cardiotoxicity is very complex and includes oxidative stress,inflammation,mitochondrial dysfunction,autophagy,cell apoptosis and death.These factors jointly promote the occurrence and development of DOX-induced cardiotoxicity.In addition,a large number of studies have shown that some active ingredients of traditional Chinese medicine antagonized DOX-induced cardiotoxicity.The combination of doxorubicin and relevant traditional Chinese medicine can maximize the therapeutic effect of tumor patients,reduce mortality rates,and improve the quality of life of tumor patients.In conclusion,this review provides new insights to further explore ingredients of traditional Chinese medicine in the treatment of DOX-induced cardiotoxicity.