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Boswellic acids:a review on its pharmacological properties,molecular mechanism and bioavailability

摘要Boswellic acids is a general term for a series of pentacyclic triterpenoid compounds that are isolated from the oleogin resin of the Boswellia genus and serve as the main active ingredient.It exhibits a wide range of biological activities,such as anti-inflammatory,anti-cancer,antibacterial,antiviral,hepatoprotective,neuroprotective,anti-diabetic,and anti-thrombotic properties.As a result,it has gained significant recognition among practitioners of traditional Chinese and Indian medicine.These biological effects may be associated with multiple molecular targets and signal transduction pathways.However,the poor pharmacokinetic properties of the substance lead to lower bioavailability,which affects its effectiveness.To address this issue,scientists have proposed a number of strategies,such as solid dispersions,phytosome? technologies,and novel drug delivery systems.This article aims to provide a comprehensive overview for boswellic acids on the phytochemistry,molecular mechanisms,potential therapeutic applications,and strategies to improve bioavailability.

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作者 Na Cui [1] Ming-Jie Li [2] Yi-Wen Wang [3] Qian Meng [4] Ya-Jun Shi [5] Yi Ding [4] 学术成果认领
作者单位 Department of Pharmacy,3201 Hospital,Hanzhong 723000,China;Department of Pharmacy,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,China;School of Pharmacy,Shaanxi University of Traditional Chinese medicine,Xianyang 712046,China [1] Department of Pharmacy,3201 Hospital,Hanzhong 723000,China [2] Department of Pharmacy,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,China;School of Pharmacy,Shaanxi University of Traditional Chinese medicine,Xianyang 712046,China [3] Department of Pharmacy,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,China [4] School of Pharmacy,Shaanxi University of Traditional Chinese medicine,Xianyang 712046,China [5]
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DOI 10.53388/TMR20240128002
发布时间 2024-11-21(万方平台首次上网日期,不代表论文的发表时间)
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