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A local-optimization refinement algorithm in single particle analysis for macromolecular complex with multiple rigid modules

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作者单位 Department of Biophysics,College of Basic Medical Sciences,Peking University Health Science Center,Beijing 100191,China ^[1] Key Lab of Intelligent Information Processing and Advanced Computing Research Lab,Institute of Computing Technology,Chinese Academy of Sciences,Beijing 100190,China;University of Chinese Academy of Sciences,Beijing 100049,China ^[2] Key Lab of Intelligent Information Processing and Advanced Computing Research Lab,Institute of Computing Technology,Chinese Academy of Sciences,Beijing 100190,China ^[3] Department of Molecular Biophysics and Biochemistry,Yale University,New Haven,CT 06511,USA ^[4] National Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China;University of Chinese Academy of Sciences,Beijing 100049,China;Center for Biological Imaging,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China ^[5]

关键词 cryo-electron microscopy single particle analysis conformational heterogeneity rigid module local optimization refinement

栏目名称

RESEARCH ARTICLES

DOI 10.1007/s13238-015-0229-2

发布时间 2016-05-24（万方平台首次上网日期，不代表论文的发表时间）

基金项目

This work was supported by grants from the Strategic Priority Research Program of Chinese Academy of Sciences （(XDB08030202)） :and F Z.,the National Basic Research Program （(973 Program) (Nos.2014CB910700 to F.S.and 2012CB917200.2010CB912400 to C.C.Y.)） and the National Natural Science Foundation of China （(Grant Nos.61232001 and 61202210)）