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Repurposing FDA-approved drugs for SARS-CoV-2 through an ELISA-based screening for the inhibition of RBD/ACE2 interaction

摘要Dear Editor,The ongoing coronavirus disease 2019(COVID-19)global pandemic is caused by a novel coronavirus,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which instigates severe and often fatal symptoms.As of September 4th,2020,more than 26 million cases of COVID-19 and almost 900,000 deaths have been reported to WHO.Based on Kissler and colleagues'modeled projections of future viral transmission scenarios,a resurgence in SARS-CoV-2 could occur over the next five years(Kissler et al.,2020).Research and clinical trials are underway to develop vacci-nes and treatments for COVID-19,but there are currently no specific vaccines or treatments for COVID-19(www.who.int),and therapeutic and prophylactic interventions are urgently needed to combat the outbreak of SARS-CoV-2.Of partic-ular importance is the identification of drugs which are effective,less-intrusive,most socioeconomic,and ready-to-use.

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作者 Wenyu Fu [1] Yujianan Chen [1] Kaidi Wang [1] Aubryanna Hettinghouse [1] Wenhuo Hu [2] Jing-Quan Wang [3] Zi-Ning Lei [3] Zhe-Sheng Chen [3] Kenneth A.Stapleford [4] Chuan-ju Liu [5] 学术成果认领
作者单位 Department of Orthopaedic Surgery,New York University Medical Center,301 East 17th Street,New York,NY 10003,USA [1] Human Oncology and Pathogenesis Program,Memorial Sloan Kettering Cancer Center,New York,NY 10065,USA [2] Department of Pharmaceutical Science,College of Pharmacy and Health Sciences,St.John's University,New York,NY 11439,USA [3] Department of Microbiology,New York University School of Medicine,New York,NY 10016,USA [4] Department of Orthopaedic Surgery,New York University Medical Center,301 East 17th Street,New York,NY 10003,USA;Department of Cell Biology,New York University School of Medicine,New York,NY 10016,USA [5]
栏目名称 LETTERS
发布时间 2021-08-25
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蛋白质与细胞

蛋白质与细胞

2021年12卷7期

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