摘要Dear Editor,The clustered regularly interspaced short palindromic repeats-Cas(CRISPR-Cas)systems,including type Ⅱ Cas9 and type ⅤCas12 systems,which serve in the adaptive immunity of prokar-yotes against viruses,have been developed into genome-editing tools(Anzalone et al.,2020;Doudna,2020).Compared with typeⅡ systems,the type V systems including V-A to V-K showed more functional diversity(Yan et al.,2019).Amongst them,Cas12i has a relatively smaller size(1,033-1,093 aa),compared to SpCas9 and Cas12a,and has a 5'-TTN protospacer adjacent motif(PAM)preference(Yan et al.,2019).
作者单位HuiEdit Therapeutics Co.,Ltd.,Shanghai 200120,China[1]HuiGene Therapeutics Co.,Ltd.,Shanghai 200120,China[2]Center for Reproductive Medicine,International Peace Maternity and Child Health Hospital,Innovative Research Team of High-level Local Universities in Shanghai,School of Medicine,Shanghai Jiao Tong University,Shanghai 200030,China[3]HuiEdit Therapeutics Co.,Ltd.,Shanghai 200120,China;HuiGene Therapeutics Co.,Ltd.,Shanghai 200120,China[4]
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