换一批摘要Unnatural amino acids (UAAs) have gained significant attention in protein engineering and drug development owing to their ability to introduce new chemical functionalities to proteins. In eukaryotes, genetic code expansion (GCE) enables the incorporation of UAAs and facilitates posttranscriptional modification (PTM), which is not feasible in prokaryotic systems. GCE is also a powerful tool for cell or animal imaging, the monitoring of protein interactions in target cells, drug development, and switch regulation. Therefore, there is keen interest in utilizing GCE in eukaryotic systems. This review provides an overview of the application of GCE in eukaryotic systems and discusses current challenges that need to be addressed.
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关键词
genetic code expansionunnatural amino acideukaryotesbasic researchtherapeutic applicationsgenetic code expansionunnatural amino acideukaryotesbasic researchtherapeutic applications
DOI
10.1093/procel/pwad051
发布时间
2025-06-27（万方平台首次上网日期，不代表论文的发表时间）
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