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The nuclear phosphoinositide-p53 signalosome in the regulation of cell motility

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摘要Dysregulation of p53 and phosphoinositide(PIPn)signaling are both key drivers of oncogenesis and metastasis.Our recent findings reveal a previously unrecognized interaction between these pathways,converging in the nucleus to form a PIPn-p53 signalosome that modulates nuclear AKT activation and downstream signaling,thereby influencing cancer cell survival and motility.This review examines recent insights into nuclear PIPn signaling in the context of established roles for p53 in cell dynamics and migration while also deliberating current research on how nuclear PIPns interact with p53 to form signalosomes that affect cell motility.We emphasize the critical role of PIPns in stabilizing p53 and activating de novo nuclear AKT signaling,which subsequently modulates key motility-related pathways.Understanding the unique operation and function of the PIPn-p53 signalosome in nuclear phosphati-dylinositol 3-kinase(PI3K)-AKT activation offers novel therapeutic strategies for controlling cancer metastasis by targeting pertinent interactions and events.

作者 Xiaoting Hou ^[1] Yu Chen ^[1] Bo Zhou ^[1] Fengting Liu ^[1] Lingyun Dai ^[2] Chunbo Chen ^[3] Noah D.Carrillo ^[4] Vincent L.Cryns ^[5] Richard A.Anderson ^[6] Jichao Sun ^[1] Mo Chen ^[1] 学术成果认领

作者单位 Department of Critical Care Medicine,Shenzhen People's Hospital(The Second Clinical Medical College,Jinan University;The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen 518020,China;Department of Geriatrics,Guangdong Provincial Clinical Research Center for Geriatrics,Shenzhen Clinical Research Center for Geriatrics,Shenzhen People's Hospital,Shenzhen 518020,China;Department of Pharmacology,Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases,SUSTech Homeostatic Medicine Institute,School of Medicine,Southern University of Science and Technology,Shenzhen 518055,China ^[1] Department of Critical Care Medicine,Shenzhen People's Hospital(The Second Clinical Medical College,Jinan University;The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen 518020,China;Department of Geriatrics,Guangdong Provincial Clinical Research Center for Geriatrics,Shenzhen Clinical Research Center for Geriatrics,Shenzhen People's Hospital,Shenzhen 518020,China ^[2] Department of Critical Care Medicine,Shenzhen People's Hospital(The Second Clinical Medical College,Jinan University;The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen 518020,China ^[3] Department of Medicine,School of Medicine and Public Health,University of Wisconsin-Madison,Madison,WI 53705,United States ^[4] Department of Medicine,School of Medicine and Public Health,University of Wisconsin-Madison,Madison,WI 53705,United States;University of Wisconsin Carbone Cancer Center,School of Medicine and Public Health,University of Wisconsin-Madison,Madison,WI 53705,United States ^[5] University of Wisconsin Carbone Cancer Center,School of Medicine and Public Health,University of Wisconsin-Madison,Madison,WI 53705,United States ^[6]

关键词 phosphoinositide p53 signalosome nucleus cell motility

栏目名称

REVIEW

DOI 10.1093/procel/pwaf043

发布时间 2025-11-25（万方平台首次上网日期，不代表论文的发表时间）

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